Research Associate / Scientist Antibody Structural Bioinformatics 100%

Festanstellung, Vollzeit · Numab Therapeutics AG

Information

In this position, you will contribute to identifying best-in-class scFvs and driving Numab’s projects towards development. You will be responsible for sequence and structure analysis for antibody engineering.

Your Responsibilities:

Perform Sanger/NGS sequence analyses and protein structure modelling using state-of-the-art in-silico methods to gain insights and guide antibody design, selection and optimization
Analyse in-silico and/or related experimental data sets (for example antibody xray/cryoEM/predicted structures and biophysical data sets)
Contribute to technology development and innovations
Develop/expand in-house data processing pipelines
Prepare and deliver reports and presentations to guide decision-making
Contribute to publications, conference presentations and patent applications

Ideal candidates will have:

Deep understanding of antibody/protein structure and solid programming skills
PhD (preferred) or MSc in computational biology, computational chemistry, theoretical chemistry, biophysical chemistry, biochemistry, chemistry, biophysics, structural biology or a related discipline with relevant industry (preferably biotech) experience
Experience in molecular modeling, molecular dynamics simulations, docking and structural bioinformatics tools and software (Discovery Studio, Rosetta, or similar) for sequence and structural analysis and structure-based antibody design and optimization
Substantial experience of working with Unix/Linux at the command-line and writing programs/scripts (e.g., format conversions, report/summary generation, etc.) to solve day-to-day problems
Proficiency in statistics and able to apply it to analysis of data and results
Familiarity with high-performance computing environments
Experience in analysis of large datasets
Ability to work independently, and willingness to take on tasks and responsibilities as needed in a dynamic cross-functional team environment
A creative and innovative mindset, with a keen interest in advancing the field of biologics through cutting-edge computational methods

What we offer:

A diverse field of activities in a dynamic team with an inspiring, entrepreneurial atmosphere.
Flat hierarchies and expedited decision-making processes.
The opportunity to take responsibility, help shaping and implementing solutions.
Attractive employment conditions, superior pension plan, flexible working time model, and opportunities for further personal development.
Performance-based bonus and participation in the employee stock option plan.
Several fun team events throughout the year.
A workplace near the city of Zurich, overlooking the lake.

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About us

Numab Therapeutics AG is an expanding, Swiss biotech company based in Horgen, canton of Zürich. The company is focused on the discovery and development of innovative, antibody fragment-based therapeutics with a focus on inflammation and immuno-oncology. With our breakthrough antibody-discovery and multi-specifics engineering platform, we engage in proprietary projects as well as collaborative research on behalf of partners in the pharmaceutical industry.

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Wir freuen uns auf Sie!

Wir freuen uns über Ihr Interesse an der Numab Therapeutics AG. Bitte füllen Sie das folgende kurze Formular aus. Sollten Sie Schwierigkeiten mit dem Upload Ihrer Daten haben, wende Sie sich gerne per Email an hr@numab.com.